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白介素18(il-18)抗體說(shuō)明書

更新時(shí)間:2012-05-24   點(diǎn)擊次數(shù):1915次

 

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BACKGROUND
Four structurally related IL­1 receptor ligands have been described. These include three agonists designated IL­1α, IL­1β and IL­1γ/IL­18 and a specific receptor antagonist, IL­1Rα. IL­1α and IL­1β play critical roles in the regula­tion of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL­18 (also referred to as IL­1γ) has been shown to augment the secretion of IFN­γ from T lymphocytes and increase NK cell activity in spleen cells. IL­18 exhibits 19% and 12% identity with IL­1α and IL­1β respectively over the twelve β­strands of the β­trefoil fold domain, which is a signature feature of the IL­1 family. The unusual leader sequence of IL­18 may be analogous to the IL­1β pro­domain which must be cleaved by the serine protease ICE for optimal secretion and biologi­cal activity. Originally described as IGIF (IFN­γ­inducing factor), IL­18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
 
 
REFERENCES
1           March, C.J., et al. 1985. Cloning, sequence and expression of two distinct human interleukin­1 complementary DNAs. Nature 315: 641­647.
2           Nakamura, K., et al. 1993. Purification of a factor which provides a co­stimulatory signal for γ interferon production. Infect. Immun. 61: 64­70.
 
 
 
CHROMOSOMAL LOCATION
Genetic locus: Il18 (mouse) mapping to 9 A5.3.
 
 
SOURCE
IL­18 (M­19) is an affinity purified goat polyclonal antibody raised against a peptide mapping at the C­terminus of IL­18 of mouse origin.
 
 
PRODUCT
Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Blocking peptide available for competition studies, sc­6179 P, (100 µg peptide in 0.5 ml PBS containing < 0.1% sodium azide and 0.2% BSA).
 
 
APPLICATIONS
IL­18 (M­19) is recommended for detection of IL­18 of mouse and rat origin by Western Blotting (starting dilution 1:200, dilution range 1:100­1:1000), immunoprecipitation [1­2 µg per 100­500 µg of total protein (1 ml of cell lysate)], immunofluorescence (starting dilution 1:50, dilution range 1:50­1:500) and solid phase ELISA (starting dilution 1:30, dilution range 1:30­1:3000).
Suitable for use as control antibody for IL­18 siRNA (m): sc­39658, IL­18 shRNA Plasmid (m): sc­39658­SH and IL­18 shRNA (m) Lentiviral Particles: sc­39658­V.
Molecular Weight of IL­18 inactive precursor: 24 kDa.
Molecular Weight of mature IL­18: 18 kDa.
Positive Controls: Mouse liver extract: sc­2256 or NIH/3T3 whole cell lysate: sc­2210.
 
 STORAGE Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non­hazardous. No MSDS required.
 
 
SELECT PRODUCT CITATIONS
1           Bisgaard, H., et al. 1999. Modulation of the gene network connected to interferon­γ in liver regeneration from oval cells. Am. J. Pathol. 155: 1075­1085.
2           Woldbaek, P.R., et al. 2003. Increased cardiac IL­18 mRNA, pro­IL­18 and plasma IL­18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction. Cardiovasc. Res. 59: 122­131.
3           van Holten, J., et al. 2004. Treatment with recombinant interferon­β reduces inflammation and slows cartilage destruction in the collagen­induced arthritis model of rheumatoid arthritis. Arthritis Res. Ther. 6: R239­R249.
4           Wang, X., et al. 2006. Disruption of interleukin­18, but not interleukin­1, increases vulnerability to preterm delivery and fetal mortality after intra­uterine inflammation. Am. J. Pathol. 169: 967­976.
5           Qiu, L., et al. 2007. Less neurogenesis and inflammation in the immature than in the juvenile brain after cerebral hypoxia­ischemia. J. Cereb. Blood Flow Metab. 27: 785­794.
6           Bergsbaken, T., et al. 2007. Macrophage activation redirects yersinia­infected host cell death from apoptosis to caspase­1­dependent pyroptosis. PLoS Pathog. 3: e161.
7           Hsiang, C.Y., et al. 2009. Nuclear factor­κB bioluminescence imaging­guided transcriptomic analysis for the assessment of host­biomaterial interaction in vivo. Biomaterials 30: 3042­3049.
8           Zhu, C., et al. 2009. Age­dependent regenerative responses in the striatum and cortex after hypoxia­ischemia. J. Cereb. Blood Flow Metab. 29: 342­354.
 
 
 
RESEARCH USE
For research use only, not for use in diagnostic procedures.

 

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